A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
Blog Article
2009, discovery of a whole new phenotype for germs in slim nanofluidic slits; and initially detection of community protein buildings together DNA working with good-point out nanopores
Our group research bacterial mobile division which is aiming to constitute a ‘bottom up biology’ in artificial cells that could autonomously divide. Our major curiosity lies in mobile division, chromatin framework, and spatial Handle.
[Laughs] ‘It absolutely was surely an incredible possibility! At enough time, I used to be effectively conscious that it could go Incorrect and that I could turn out to be much less successful, but I just disregarded that. Curiosity has generally been my strongest driving pressure. And fortuitously it all labored out.’
Our get the job done was promptly adopted up by Many others, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 posted their findings on transistors created from single- and multi-walled carbon nanotubes in Applied Physics Letters.
Your browser isn’t supported anymore. Update it to find the finest YouTube expertise and our latest capabilities. Learn more
The coiled-coil of your human Rad50 DNA mend protein consists of unique segments of enhanced flexibility
What distinguishes biology from chemistry is usually that these elements alongside one another make up a residing procedure. The key of reported existence, I do think, lies inside the interactions, the interaction of These molecules. The massive question with regards to the origin of lifestyle remains to be unanswered. How did we at any time evolve from easy molecules in the very intricate systems we see right now? We do not know. I want to work on These types of significant, open queries.’
Nanopores signify an elegant and flexible Instrument to measure single molecules. We study novel detection modes with strong-state nanopores in addition to numerous methods to measure proteins with nanopores. Projects encompass the subsequent:
‘You should not just take into consideration the inquiries of tomorrow, but in addition look at the issues of the day after tomorrow’
Quite neat, but that wasn’t actually where by my interest lay. I wished to pioneer and I had the sensation which was no longer achievable, as the most interesting basic insights experienced now been uncovered. But my area had designed lots of fascinating new equipment to evaluate individual ceesdekker.net molecules. I decided that I wished to implement this to biology, to have a look at it from the physical perspective.’
‘The concept that You can find such a factor being a starting, a huge bang, is now a fascinating signpost to think about that there was a creator. But far more commonly, and on The premise of pure rationality, I also get there in a Christian interpretation of truth. An atheistic worldview is a naturalistic worldview: fundamentally, you'll find only atoms and normal forces that we could evaluate.
‘That problems the synthetic cell, as Component of the Dutch BaSyC initiative. Craig Venter looked prime-down in those days and discovered about five hundred genes which might be minimally demanded for any operating mobile. We want to seem base-up: how do we shift from a handful of molecules to an entire Organic method?
Visualization of unstained DNA nanostructures with Innovative in-aim transmission electron microscopy techniques
Good-point out nanopores have tested to be a surprisingly versatile probe for single-molecule analysis of DNA. I will explain many of our the latest conclusions – precisely DNA knots – and our endeavours to develop the abilities of reliable-condition nanopores even additional, within the direction of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.